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The following term was not found in PubMed: HMJ2-1
Page 1
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension.
Hennigs JK, Cao A, Li CG, Shi M, Mienert J, Miyagawa K, Körbelin J, Marciano DP, Chen PI, Roughley M, Elliott MV, Harper RL, Bill MA, Chappell J, Moonen JR, Diebold I, Wang L, Snyder MP, Rabinovitch M. Hennigs JK, et al. Circ Res. 2021 Feb 5;128(3):401-418. doi: 10.1161/CIRCRESAHA.119.316339. Epub 2020 Dec 16. Circ Res. 2021. PMID: 33322916 Free PMC article.
RATIONALE: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcription factors, PPARgamma (p …
RATIONALE: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damag …
Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling.
Mao C, Ma Z, Jia Y, Li W, Xie N, Zhao G, Ma B, Yu F, Sun J, Zhou Y, Cui Q, Fu Y, Kong W. Mao C, et al. Circulation. 2021 Oct 12;144(15):1244-1261. doi: 10.1161/CIRCULATIONAHA.120.053361. Epub 2021 Jul 28. Circulation. 2021. PMID: 34315224
Indeed, nidogen-2-deficient VSMCs exhibited loss of contractile phenotype in vitro, and compared with wild-type mice, nidogen-2(-/)(-) mice showed aggravated post-wire injury neointima formation of carotid arteries. ...Reciprocally, Jagged1 and Notch3 …
Indeed, nidogen-2-deficient VSMCs exhibited loss of contractile phenotype in vitro, and compared with wild-type mice, nidogen- …
Regulatory role and translational potential of CCL11 in liver fibrosis.
Kong M, Dong W, Kang A, Kuai Y, Xu T, Fan Z, Shi L, Sun D, Lu Y, Li Z, Xu Y. Kong M, et al. Hepatology. 2023 Jul 1;78(1):120-135. doi: 10.1097/HEP.0000000000000287. Epub 2023 Jan 19. Hepatology. 2023. PMID: 36651177
APPROACH AND RESULTS: We report that CCL11 levels were elevated in HSCs, but not in hepatocytes or Kupffer cells, isolated from mice with liver fibrosis compared with the control mice. CCL11 levels were also up-regulated by 2 pro-fibrogenic growth factors TGF …
APPROACH AND RESULTS: We report that CCL11 levels were elevated in HSCs, but not in hepatocytes or Kupffer cells, isolated from mice …
Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.
Tindemans I, Lukkes M, de Bruijn MJW, Li BWS, van Nimwegen M, Amsen D, KleinJan A, Hendriks RW. Tindemans I, et al. J Allergy Clin Immunol. 2017 Oct;140(4):1079-1089. doi: 10.1016/j.jaci.2016.11.046. Epub 2017 Jan 19. J Allergy Clin Immunol. 2017. PMID: 28111308
RESULTS: HDM exposure promoted expression of Jagged 1, but not Jagged 2, on DCs. In agreement with published findings, in vitro-differentiated and HDM-pulsed Jagged 1 and Jagged 2 double-deficient DCs lacked the capacity to induce AAI. Ho …
RESULTS: HDM exposure promoted expression of Jagged 1, but not Jagged 2, on DCs. In agreement with published findings, …
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.
Cao Z, Lis R, Ginsberg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S, Ding BS. Cao Z, et al. Nat Med. 2016 Feb;22(2):154-62. doi: 10.1038/nm.4035. Epub 2016 Jan 18. Nat Med. 2016. PMID: 26779814 Free PMC article.
Using intratracheal injection of bleomycin or hydrochloric acid in mice, we show that repetitive lung injury activates pulmonary capillary endothelial cells (PCECs) and perivascular macrophages, impeding alveolar repair and promoting fibrosis. ...
Using intratracheal injection of bleomycin or hydrochloric acid in mice, we show that repetitive lung injury activates pulmonary capi …
Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency.
Yao Y, Yao J, Radparvar M, Blazquez-Medela AM, Guihard PJ, Jumabay M, Boström KI. Yao Y, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19071-6. doi: 10.1073/pnas.1310905110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191040 Free PMC article.
Subsequent activation of activin receptor-like kinase 1 enhances expression of Notch ligands Jagged 1 and 2, which increases Notch activity and alters the expression of Ephrin B2 and Ephrin receptor B4, arterial and venous endothelial markers, respectively. Reducing …
Subsequent activation of activin receptor-like kinase 1 enhances expression of Notch ligands Jagged 1 and 2, which increases N …
Lysine-specific demethylase 1 induced epithelial-mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway.
Zhang H, Xing J, Zhao L. Zhang H, et al. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S203-S214. doi: 10.1177/09603271211038743. Epub 2021 Aug 16. Hum Exp Toxicol. 2021. PMID: 34396798
Protein expression of LSD1, E-cadherin, a-smooth muscle actin (a-SMA), Vimentin, Jagged-1, Notch-1 and Notch-2 were detected by Western blot. The concentrations of type I collagen (Col-I) and Fibronectin (FN) were measured by ELISA. ...Moreover, knockdown of LSD1 su …
Protein expression of LSD1, E-cadherin, a-smooth muscle actin (a-SMA), Vimentin, Jagged-1, Notch-1 and Notch-2 were detected b …
Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease.
Kimura S, Dupee Z, Lima F, Allen R, Kazmi S, Diodati N, Lukacs NW, Kunkel SL, Schaller M. Kimura S, et al. Immunohorizons. 2023 Feb 1;7(2):168-176. doi: 10.4049/immunohorizons.2300001. Immunohorizons. 2023. PMID: 36729482 Free PMC article.
The goal of our studies was to determine the role of Jagged-1 in the pathogen-free inflammation induced by OVA during allergic airway disease in mice. Our studies show that a deletion in DC-expressed Jagged-1 causes a significant increase in cytokine producti …
The goal of our studies was to determine the role of Jagged-1 in the pathogen-free inflammation induced by OVA during allergic airway …
Adipose-Derived Mesenchymal Stem Cell Facilitate Hematopoietic Stem Cell Proliferation via the Jagged-1/Notch-1/Hes Signaling Pathway.
Wang H, Bi X, Zhang R, Yuan H, Xu J, Zhang K, Qi S, Zhang X, Jiang M. Wang H, et al. Stem Cells Int. 2023 Nov 9;2023:1068405. doi: 10.1155/2023/1068405. eCollection 2023. Stem Cells Int. 2023. PMID: 38020206 Free PMC article.
Therefore, this study aimed to investigate the mechanisms underlying the long-term hematopoietic support provided by ADSCs. METHODS: ADSCs were isolated from mice and subsequently identified. In vitro experiments involved coculturing ADSCs as feeders with Lin-Sca-1(+)c-kit …
Therefore, this study aimed to investigate the mechanisms underlying the long-term hematopoietic support provided by ADSCs. METHODS: ADSCs w …
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.
Guo P, Poulos MG, Palikuqi B, Badwe CR, Lis R, Kunar B, Ding BS, Rabbany SY, Shido K, Butler JM, Rafii S. Guo P, et al. J Clin Invest. 2017 Dec 1;127(12):4242-4256. doi: 10.1172/JCI92309. Epub 2017 Oct 23. J Clin Invest. 2017. PMID: 29058691 Free PMC article.
We used mice with EC-specific deletion of the gene encoding jagged-2 (Jag2) to demonstrate that while EC-derived jagged-2 was dispensable for maintaining the capacity of HSPCs to repopulate under steady-state conditions, by activating Notch2 it …
We used mice with EC-specific deletion of the gene encoding jagged-2 (Jag2) to demonstrate that while EC-derived jag …
461 results